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Inhibition of hormone‐sensitive lipase by intermediary lipid metabolites
Author(s) -
Jepson Catherine A.,
Yeaman Stephen J.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81328-j
Subject(s) - monoacylglycerol lipase , lipase , hormone sensitive lipase , oleic acid , chemistry , enzyme , biochemistry , lipid metabolism , fatty acid , lipoprotein lipase , cholesterol , metabolism , endocannabinoid system , receptor
Hormone‐sensitive lipase (HSL) is inhibited in a non‐competitive manner by oleoyl CoA, oleic acid and 2‐monopalmitoylglycerol, 50% inhibition being observed at concentrations of approx. 0.1 μM, 0.5 μM and 500 μM, respectively. HSL is a key enzyme in lipid metabolism, mobilising triacylglycerol and cholesterol ester stores in several tissues. Feedback inhibition of HSL by oleoyl CoA and oleic acid may therefore prevent accumulation of free fatty acids and cholesterol in the cell, whereas 2‐monoacylglycerol may act as a feedback inhibitor if the capacity of monoacylglycerol lipase is exceeded.