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The 26 S proteasome is activated at two points in the ascidian cell cycle
Author(s) -
Kawahara Hiroyuki,
Sawada Hitoshi,
Yokosawa Hideyoshi
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81310-i
Subject(s) - proteasome , microbiology and biotechnology , proteolysis , mitosis , cell cycle , metaphase , prophase , cell , biology , embryonic stem cell , chemistry , biochemistry , enzyme , gene , meiosis , chromosome
The proteasome undergoes cell cycle‐dependent changes in its subcellular distribution during ascidian embryonic development [(1992) Dev. Biol. 151, 27–33]. In this study, we demonstrate that the 26 S proteasome is markedly activated in both prophase and metaphase of the mitotic cell cycle in the ascidian embryos in comparison with the case of the 20 S proteasome. These results suggest that the 26 S proteasome is activated and participates in proteolysis at the restricted stages of the cell cycle.