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Flow‐induced prostacyclin production is mediated by a pertussis toxin‐sensitive G protein
Author(s) -
Berthiaume Francois,
Frangos John A.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81292-t
Subject(s) - pertussis toxin , prostacyclin , chemistry , g protein , biochemistry , receptor
Fluid flow and several other agonists induce prostacyclin (PGI 2 ) production in endothelial cells, G proteins mediate the response of a large number of hormones such as histamine, but the transduction pathway of the flow signal is unclear. We found that GDPβS and pertussis toxin inhibited flow‐induced prostacyclin production in human umbilical vein endothelial cells. In addition, flow potentiated the histamine‐induced production of PGI 2 . This suggests that flow stimulates prostacyclin production via a pertussis toxin‐sensitive G protein and modulates the stimulus‐response coupling of other agonists.