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Vitamin E dietary supplementation inhibits transforming growth factor β1 gene expression in the rat liver
Author(s) -
Parola Maurizio,
Muraca Roberto,
Dianzani Irma,
Barrera Giuseppina,
Leonarduzzi Gabriella,
Bendinelli Paola,
Piccoletti Roberta,
Poli Giuseppe
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81290-3
Subject(s) - endocrinology , medicine , transforming growth factor , vitamin , basal (medicine) , gene expression , transforming growth factor beta , procollagen peptidase , fibrosis , biology , messenger rna , ccl4 , carbon tetrachloride , chemistry , gene , biochemistry , insulin , organic chemistry
Overexpression of transforming growth factor β1 (TGFβ1) and increased transcription of pro‐collagen type I, are known to represent major events implicated in the development of liver fibrosis under either experimental or clinical conditions. Here we report that long‐term dietary vitamin E supplementation in animals undergoing an experimental model of liver fibrosis (induced by chronic treatment of rats with carbon tetrachloride) results in a net inhibition of both hepatic TGFβ1 and α2 (I) procollagen mRNA levels. Moreover, of striking interest is the observation that vitamin E supplementation per so down‐modulates basal levels of TGFβ1 mRNA in the liver of untreated animals, suggesting that a dietary regimen rich in vitamin E may potentially interfere with both the initiation and progression of the fibrosclerotic processes.