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Rat liver BiP/GRP78 is down‐regulated by a peroxisome‐proliferator, clofibrate
Author(s) -
Motojima Kiyoto,
Goto Sataro
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81275-q
Subject(s) - clofibrate , peroxisome , complementary dna , peroxisome proliferator , cloning (programming) , messenger rna , chemistry , peroxisome proliferator activated receptor , microbiology and biotechnology , biochemistry , endocrinology , biology , receptor , gene , computer science , programming language
Administration of clofibrate in rat results in down‐regulation of several liver proteins and a vast induction of peroxisomal proteins. One protein was identified as BiP/GRP78 using antibodies and cDNA cloning. The level of mRNA was reduced by the drug.