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Human immunodeficiency virus type 1 productive infection in staurosporine‐blocked quiescent cells
Author(s) -
Aranda-Anzaldo A.,
Viza D.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81268-q
Subject(s) - staurosporine , virology , biology , virus , kinase , human immunodeficiency virus (hiv) , cell cycle , microbiology and biotechnology , cell , immunology , protein kinase a , genetics
Staurosporine, an antibiotic known to inhibit cellular protein kinases, can reversibly block the progress of normal and tumour cells into the cell cycle. The ability of HIV‐1 to infect and replicate in cells blocked by staurosporine was investigated. The results show that blocked, non‐cycling cells can be productively infected by HIV‐1, steadily releasing infectious progeny virus for several weeks. This suggests that at least in some cases, HIV‐1 can be found in a stable and active state in resting, non‐proliferating T cells.