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Progesterone action through aggregation of a receptor on the sperm plasma membrane
Author(s) -
Tesarik J.,
Mendoza C.,
Moos J.,
Fénichel P.,
Fehlmann M.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81256-l
Subject(s) - receptor , mechanism of action , steroid , chemistry , cell membrane , microbiology and biotechnology , sperm , hormone , cell surface receptor , steroid hormone , cell , mechanism (biology) , antibody , membrane , cell type , biophysics , medicine , biology , endocrinology , biochemistry , in vitro , immunology , genetics , philosophy , epistemology
Rapid steroid effects, reported in several cell types, have pointed out the possibility of non‐genomic mechanisms of action, presumably on cell surface receptors. Here we analyzed the effects of antibody‐mediated aggregation of a novel type of progesterone receptor on the plasma membrane of human sperm cells. We report that aggregation of hormone‐receptor complexes induces Ca 2+ influx and a Ca 2+ ‐dependent exocytotic event in this system. These data suggest a possible mechanism for rapid steroid‐induced events. Further research is warranted to examine if a similar mechanism is involved in rapid steroid effects in other cell types.