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Curcumin inhibits nitrite‐induced methemoglobin formation
Author(s) -
Unnikrishnan M.K.,
Rao M.N.A.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81246-i
Subject(s) - methemoglobin , nitrite , chemistry , hemoglobin , superoxide , curcumin , autocatalysis , heme , biochemistry , organic chemistry , catalysis , enzyme , nitrate
Curcumin protects hemoglobin from nitrite‐induced oxidation to methemoglobin. The protection is not observed when curcumin is added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of curcumin to scavenge superoxide may be responsible since superoxide is implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite.