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The length of the interdomain region of the L7/L12 protein is important for its function
Author(s) -
Bubunenko M.G.,
Chuikov S.V.,
Gudkov A.T.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81198-u
Subject(s) - function (biology) , amino acid , amino acid residue , chemistry , biochemistry , biology , peptide sequence , microbiology and biotechnology , gene
Several mutated L7/L12 proteins with changed interdomain regions were obtained. The results showed that the flexible region comprising the 39–52 amino acid residues is functionally important. Its length, but not its amino acid composition, is crucial for the function.