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Interferon‐mediated intracellular signalling Modulation of different phospholipase activities in Burkitt lymphoma cells
Author(s) -
Cataldi A.,
Rana R.,
di Primio R.,
Bareggi R.,
Lisio R.,
Toto N.,
Miscia S.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81193-p
Subject(s) - phospholipase c , phospholipase d , phospholipase , intracellular , chemistry , phosphatidylcholine , interferon , lymphoma , microbiology and biotechnology , biochemistry , enzyme , biology , immunology , phospholipid , membrane
The effect of interferon‐α on Daudi lymphoma cells either sensitive or resistant to the action of this cytokine has been analysed in terms of phospholipase C (PLC) and D (PLD) activities. Results have shown a combined modulation of PIP 2 ‐specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP 2 ‐specific PLC has been found, concomitant to a PLD‐mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signaling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway.