Premium
Human interleukin‐1 receptor antagonist is expressed in liver
Author(s) -
Steinkasserer Alexander,
Estaller Cornelia,
Weiss Elisabeth H.,
Sim Robert B.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81146-d
Subject(s) - interleukin 1 receptor antagonist , complementary dna , northern blot , microbiology and biotechnology , receptor antagonist , interleukin 1 receptor, type i , interleukin 12 receptor, beta 1 subunit , antagonist , interleukin 21 receptor , biology , receptor , cdna library , coding region , messenger rna , gene , biochemistry
Using PCR and Northern blot analysis, an IL‐1 receptor antagonist specific transcript was amplified from HepG2‐ and liver mRNA, cDNA clones coding for IL‐1 receptor antagonist were isolated from a liver cDNA library and sequence comparison revealed complete identity with the secreted, monocytic form of IL‐1 receptor antagonist.