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IL‐4 inhibits LPS‐, IL‐1β‐ and TNFα‐induced expression of tissue factor in endothelial cells and monocytes
Author(s) -
Herbert J.M.,
Savi P.,
Laplace M.C.,
Lale A.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81139-d
Subject(s) - tissue factor , umbilical vein , tumor necrosis factor alpha , monocyte , interleukin , interleukin 19 , chemistry , endothelial stem cell , microbiology and biotechnology , cytokine , immunology , biology , medicine , in vitro , coagulation , biochemistry , interleukin 5
Inflammatory mediators such as endotoxin, interleukin‐1β(IL‐1β) and tumor necrosis factors‐α (TNF‐α) dose‐dependently increased the expression of tissue factor on the surface of cultured bovine aortic endothelial cells (ABAE), human umbilical vein endothelial cells (HUVEC) and human monocytes. In ABAE, endotoxin‐, IL‐1β‐ and TNFα‐induced tissue factor expression was suppressed by interleukin‐4 (IL‐4) which also neutralized the pyrogenic effect of endotoxin in HUVEC and monocytes. IL‐4 did not alter TNF‐α‐induced procoagulant changes in HUVEC and monocytes but strongly protected the monocyte surface against IL‐1β‐induced procoagulant changes.