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Relationship between primary structure and activity in exorphins and endogenous opioid peptides
Author(s) -
Ya. Bakalkin Georgy,
Demuth Hans-Ulrich,
Nyberg Fred
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81135-9
Subject(s) - protein primary structure , peptide , endogeny , opioid peptide , primary (astronomy) , endogenous opioid , chemistry , structure–activity relationship , opioid , stereochemistry , biochemistry , peptide sequence , receptor , in vitro , physics , gene , astronomy
We have found a correlation between the certain characteristics of primary structure and biologic activity in exorphins and endogenous opioid peptide family. The characteristics of primary structure are the content of certain segment pairs as well as the density of their arrangement in a peptide. These segment pairs represent basic elements of the regulatory peptide primary structure pattern, which was found recently [Dokl. Akad. Nauk USSR 289 (1986) 721–724; Int. J. Peptide Prot. Res. 38 (1991) 505–510].