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The angiotensin AT 2 receptor modulates T‐type calcium current in non‐differentiated NG108‐15 cells
Author(s) -
Buisson Bruno,
Bottari Serge P.,
de Gasparo Marc,
Gallo-Payet Nicole,
Payet Marcel D.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81086-2
Subject(s) - angiotensin ii , receptor , calcium , endocrinology , chemistry , biophysics , medicine , voltage dependent calcium channel , calcium signaling , microbiology and biotechnology , biology , biochemistry
We report here that angiotensin II (AII) and the AT 2 receptor‐selective ligand, CGP 42112, modulate the T‐type calcium current in non‐differentiated NG108‐15 cells, which express only AT 2 receptors. Both peptides decrease the T‐type calcium current at membrane potentials above −40 mV and shift the current—voltage curve at lower potentials with maximal effect between 5 and 10 min after application. These data describe a new cellular response to AII and suggest that the AT 2 receptor mediates certain neurophysiological actions of this hormone.