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α2‐Macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells
Author(s) -
De Strooper Bart,
Van Leuven Fred,
Van Den Berghe Herman
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81048-q
Subject(s) - macroglobulin , secretion , amyloid precursor protein , intracellular , amyloid precursor protein secretase , compartment (ship) , neuroblastoma , cell culture , biochemistry , chemistry , protein precursor , biology , microbiology and biotechnology , enzyme , medicine , alzheimer's disease , disease , oceanography , genetics , geology
A series of proteinase inhibitors active against proteinases of all four major classes, including highly purified and well‐characterized α2‐macroglobulin, added to the cell culture medium of murine Neuro 2a neuroblastoma cells did not interfere with APP secretase activity. We therefore advance the hypothesis that APP secretase activity is localized in an intracellular compartment.