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Induction of Ca 2+ /calmodulin‐dependent NO synthase in various organs of rats by Propionibacterium acnes and lipopolysaccharide treatment
Author(s) -
Oguchi Shinobu,
Iida Sachio,
Adachi Hiroko,
Ohshima Hiroshi,
Esumi Hiroyasu
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81041-j
Subject(s) - propionibacterium acnes , calmodulin , nitric oxide synthase , lipopolysaccharide , atp synthase , microbiology and biotechnology , spleen , enzyme , western blot , chemistry , nitric oxide , biochemistry , biology , bacteria , endocrinology , immunology , gene , genetics
Ca 2+ /calmodulin‐dependent nitric oxide synthase was found to be induced during rat liver necrosis caused by administration of Propionibacterium acnes and E. coli lipopolysaccharide to rats. Examination of the specific induction of C a2+ /calmodulin‐dependent NO synthase showed that the enzyme was induced in the lung, spleen and colon as well as the liver. Northern blot analysis revealed that the induction occurred at the transcriptional level.