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Molecular cloning and characterization of a novel calcium channel from rabbit brain
Author(s) -
Niidome Tetsuhiro,
Kim Man-Suk,
Friedrich Thomas,
Mori Yasuo
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81038-n
Subject(s) - calcium channel , complementary dna , in situ hybridization , striatum , calcium , n type calcium channel , cloning (programming) , r type calcium channel , hippocampus , voltage dependent calcium channel , microbiology and biotechnology , t type calcium channel , biology , molecular cloning , calcium binding protein , biochemistry , chemistry , neuroscience , gene , messenger rna , organic chemistry , computer science , dopamine , programming language
The complete amino acid sequence of a novel calcium channel (designated BII) from rabbit brain has been deduced by cloning and sequencing the cDNA. The BII calcium channel is structurally more closely related to the BI calcium channel than to the cardiac and skeletal muscle L‐type calcium channels. Blot hybridization analysis of RNA from different tissues and from different regions of the brain shows that the BII calcium channel is distributed predominantly in the brain, being abundant in the cerebral cortex, hippocampus and corpus striatum.