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Bleomycin‐reactive iron in patients with acute non‐lymphocytic leukemia
Author(s) -
Gordeuk Victor R.,
Brittenham Gary M.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81037-m
Subject(s) - bleomycin , chronic lymphocytic leukemia , acute leukemia , medicine , acute lymphocytic leukemia , leukemia , lymphoblastic leukemia , chemotherapy
Bleomycin‐reactive iron was detected in the sera of six out of nine adults undergoing intensive chemotherapy for acute non‐lymphocytic leukemia. In these individuals the corresponding transferrin saturation ranged from 96% to 113% and the serum ferritin from 775 to 9975 μg/l. Nontransferrin‐bound iron has been postulated to be a factor in organ toxicity in iron overload conditions such as beta thalassemia and hereditary hemochromatosis by facilitating the production of tissue‐damaging free radicals. We propose that bleomycin‐reactive iron should be considered as a possible factor in organ dysfunction seen with intensive cancer chemotherapy.