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Expression of c‐ fos , c‐ jun , jun ‐B, metallothionein and metalloproteinase genes in human chondrocyte
Author(s) -
Zafarullah Muhammad,
Martel-Pelletier Johanne,
Cloutier Jean-Marie,
Gedamu Lashitew,
Pelletier Jean-Pierre
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80992-p
Subject(s) - chondrocyte , metallothionein , c jun , microbiology and biotechnology , gene , metalloproteinase , gene expression , messenger rna , biology , matrix metalloproteinase , chemistry , cartilage , biochemistry , transcription factor , anatomy
Normal and osteoarthritic (OA) human articular cartilage chondrocytes, released enzymatically in the presence of 0.5% fetal calf serum, display constitutive expression of early response activating protein (AP‐1) genes; c‐ fos , c‐ jun and jun ‐B. Among the late AP‐1 responsive genes, total matallothionein (MT) and stromelysin mRNAs were expressed at high levels in both normal and OA chondrocytes, while collagenase and hMT‐II A mRNA levels were elevated only in OA individuals. Despite the common AP‐1 sequences present in their promoter regions, the three late genes were differentially expressed.