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Identification of four FGF receptor genes in Medaka fish ( Oryzias latipes )
Author(s) -
Emori Yasufumi,
Yasuoka Akihito,
Saigo Kaoru
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80968-m
Subject(s) - oryzias , biology , complementary dna , fibroblast growth factor , gene , alternative splicing , genetics , homologous chromosome , microbiology and biotechnology , fibroblast growth factor receptor 1 , reverse transcriptase , receptor , polymerase chain reaction , exon
Four types of cDNA clones encoding tyrosine kinases highly homologous to mammalian fibroblast growth factor receptors (FGF‐R) were isolated from Medaka fish ( Oryzias latipes ) by the reverse transcription‐polymerase chain reaction. Comparison of the four deduced amino acid sequences with four known mammalian FGF‐Rs indicated that four FGF‐R species corresponding to mammalian FGF‐Rs exist universally in vertebrates including fishes, although FGF‐R4 might have diverged sequences between fishes and mammals. Each of four FGF‐R genes is transcribed to various extents as multiple mRNAs possibly by alternative splicing in adult fishes.