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Do G protein subunits associate via a three‐stranded coiled coil?
Author(s) -
Lupas Andrei N.,
Lupas Janice M.,
Stock Jeffry B.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80952-d
Subject(s) - coiled coil , protein subunit , domain (mathematical analysis) , terminal (telecommunication) , chemistry , association (psychology) , biophysics , biology , microbiology and biotechnology , crystallography , biochemistry , computational biology , computer science , mathematics , psychology , mathematical analysis , telecommunications , gene , psychotherapist
We used a computer‐based prediction algorithm to identify probable coiled‐coil segments at the N‐termini of G protein α, β and γ subunits. This result indicates that G protein trimers may form via a three‐stranded coiled coil. Previous biochemical results had shown that the N‐termini of α and β are involved in subunit interactions. Here we present a structural model for the N‐terminal domain of βγ and a hypothesis for the reversible association of α to βγ.