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NO • , CO and • OH Endogenous soluble guanylyl cyclase‐activating factors
Author(s) -
Schmidt Harald H.H.W.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80910-9
Subject(s) - soluble guanylyl cyclase , chemistry , guanosine , guanylate cyclase , cyclic guanosine monophosphate , nitric oxide , intracellular , carbon monoxide , guanylate cyclase 2c , gucy2d , hydroxyl radical , endogeny , biochemistry , cyclase , signal transduction , gucy1a3 , gucy1b3 , biophysics , enzyme , radical , biology , organic chemistry , catalysis
Several low molecular weight compounds are capable of activating soluble guanylyl cyclase. Recent evidence suggests that some of these are formed under physiological conditions: the nitric oxide radical, carbon monoxide and the hydroxyl radical. Thus, multiple signal transduction pathways appear to exist that form a family of guanylyl cyclase activating factors and thereby regulate the intracellular cyclic guanosine 3′, 5′‐monophosphate level.