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Neurotransmitter transporters A novel family of integral plasma membrane proteins
Author(s) -
Schloss Patrick,
Mayser Wolfgang,
Betz Heinrich
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80905-v
Subject(s) - neurotransmitter transporter , transporter , neurotransmission , neurotransmitter , microbiology and biotechnology , synaptic plasticity , integral membrane protein , transmembrane protein , biology , chemistry , neuroscience , membrane protein , biochemistry , central nervous system , gene , membrane , receptor
The re‐uptake of neurotransmitters into the nerve terminal terminates synaptic transmission at most central synapses and constitutes a key step in the modulation of synaptic efficacy. Recently, the cloning of several Na + ‐driven neurotransmitter transporters has resulted in the description of a novel family of homologous membrane proteins, each with 12 transmembrane segments. These transporters constitute major targets of widely used drugs, and modulation of transporter gene expression and/or activity may represent an important substrate for plasticity in the nervous system.