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Prokaryotic polyprotein precursors
Author(s) -
Thöny-Meyer Linda,
Böck august,
Hennecke Hauke
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80902-s
Subject(s) - polyproteins , proteases , function (biology) , gene , biology , chemistry , microbiology and biotechnology , biochemistry , computational biology , enzyme , genome
Polyproteins have been found only recently in prokaryotes. The four known examples of single bacterial genes encoding precursors that are posttranslationally processed into two mature proteins are addressed here with respect to (i) their genomic arrangement, (ii) the sites of proteolytic processing, (iii) the relevant proteases, (iv) their maturation pathway, and (v) the function of the mature proteins. How these polyproteins may have evolved is also discussed.