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SH3 — an abundant protein domain in search of a function
Author(s) -
Musacchio Andrea,
Gibson Toby,
Lehto Veli-Pekka,
Saraste Matti
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80901-r
Subject(s) - sh3 domain , homology (biology) , cytoskeleton , proto oncogene tyrosine protein kinase src , microbiology and biotechnology , signal transduction , chemistry , domain (mathematical analysis) , signal transducing adaptor protein , computational biology , function (biology) , biochemistry , amino acid , biology , biophysics , cell , mathematical analysis , mathematics
Src‐homology 3 is a small protein domain of about 60 amino acid residues. It is probably made of β‐sheets. SH3 is present in a large number of eukaryotic proteins which are involved in signal transduction, cell polarization and membrane—cytoskeleton interactions. Here we review its occurrence and discuss possible functions of this domain.