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Understanding the functions of titin and nebulin
Author(s) -
Trinick John
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80899-r
Subject(s) - titin , nebulin , sarcomere , obscurin , protein filament , myosin , actin , myosin head , biophysics , chemistry , microbiology and biotechnology , myosin light chain kinase , biology , biochemistry , myocyte
Individual molecules of the giant muscle proteins titin and nebulin span large distances in the sarcomere. Approximately one‐third of the titin molecule forms elastic filaments linking the ends of thick filaments to the Z‐line. The remainder of the molecule is probably bound to the thick filament where it may regulate assembly of myosin and the other thick filament proteins. This region also contains a sequence similar to catalytic domains in protein kinases. Nebulin appears to be associated with thin filaments and may regulate actin assembly.