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Multidomain enzymes involved in peptide synthesis
Author(s) -
Marahiel Mohamed A.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80898-q
Subject(s) - peptide , chemistry , enzyme , biochemistry
Biosynthesis of peptides in non‐ribosomal systems is catalyzed by multifunctional enzymes that employ the thio‐template mechanism. Recent studies on the analysis of the primary structure of several peptide synthetases have revealed that they are organized in highly conserved and repeated functional domains. The aligned domains provide the template for peptide synthesis, and their order determines the sequence of the peptide product.