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Characterization of carbohydrates in the α 2 ‐macroglobulin receptor
Author(s) -
Jensen Poul H.,
Gliemann Jørgen,
Ørntoft Torben
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80879-l
Subject(s) - macroglobulin , biochemistry , receptor , methylamine , carbohydrate , chemistry
Carbohydrates were characterized in the human placental α 2 ‐macroglobulin receptor and its associated protein. Carbohydrates, largely N‐linked, contributed to about 18% of the size of the receptor α‐chain and to about 25% of the β‐chain. The 40 kDa receptor‐associated Protein also contained carbohydrate. The α‐ and β‐chains contained a wide variety of carbohydrates as judged by binding of lectins. Monosaceharide‐competing inhibition of α 2 M‐methylamine binding by WGA suggested a functional significance of sugars in binding of ligands to the α‐chain.