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A large domain common to sperm receptors (Zp2 and Zp3) and TGF‐β type III receptor
Author(s) -
Bork Peer,
Sander Chris
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80853-9
Subject(s) - receptor , biology , genetics
A new family of mosaic proteins is defined by sequence analysis. The family is characterized by a 260 residue domain common to proteins of apparently diverse function and tissue specificity; sperm receptors Zp2 and Zp3, betaglycan (also called TGF‐β type III receptor), uromodulin, as well as the major zymogen granule membrane protein (GP‐2). The location of the common domain is similar with respect to putative transmembrane regions. The results lead to the hypothesis that this type of domain has a common tertiary structure and that there is a functional similarity in the recognition mechanism of the sperm receptor system and the TGF‐β receptor complex.