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Latrotoxin‐like properties of a protein from brain
Author(s) -
Zhukareva V.A.,
Shatursky O.Ya.,
Lishko V.K.,
Malysheva M.K.,
Terletskaya Ya.T.,
Tsygankova O.M.,
Grishin E.V.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80849-c
Subject(s) - polyclonal antibodies , liposome , cytoplasm , chemistry , biophysics , biochemistry , antibody , biology , immunology
In bovine brain cortex cytoplasm we have identified a soluble protein (L‐protein) of M r ∼90 kDa interacting with polyclonal antibodies to α‐latrotoxin. The L‐protein forms potential‐dependent and cation‐selective ion channels in BLM, which are blocked by Cd 2+ . The fusogenic activity of the L‐protein was demonstrated on liposomes. We have arrived at the conclusion that the action mechanisms of the L‐protein and α‐latrotoxin are similar.