Premium
Expression of protein kinase C subspecies in rat retina
Author(s) -
Fujisawa Naoko,
Ogita Kouji,
Saito Naoaki,
Nishizuka Yasutomi
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80818-2
Subject(s) - retina , subspecies , microbiology and biotechnology , chemistry , protein kinase a , kinase , biology , neuroscience , zoology
An extract of rat retina was subjected to Mono Q followed by chromatography on hydroxyapatite, and the protein kinase C (PKC) subspecies were identified by immunobiol and biochemical analysis. It was found that, although the relative activities assayed with myelin basic protein as a common phosphate acceptor vary greatly with one another, the α‐, βI‐, βII‐, γ‐, δ‐, ε‐, ξ‐, and another structurally unknown PKC subspecies are expressed in this tissue. Thus, the retina is a unique tissue which expresses most of the PKC subspecies so far identified in mammals.