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Synthesis of active metabolite(s) from 1α‐hydroxyvitamin D 3 by human monocytic leukemia cells
Author(s) -
Okabe-Kado Junko,
Honma Yoshio,
Kasukabe Takashi,
Hozumi Motoo
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80815-x
Subject(s) - metabolite , leukemia , alpha (finance) , monocytic leukemia , cell culture , u937 cell , active metabolite , biological activity , acute monocytic leukemia , thp1 cell line , chemistry , biochemistry , biology , medicine , in vitro , immunology , construct validity , genetics , nursing , patient satisfaction
Synthesis of the biologically active metabolite(s) from 1α‐hydroxyvitamin D 3 (1α(OH)D 3 ) was examined in various types of human leukemia cell lines. Untreated monocytoid leukemia cells (U937 and HE/S) metabolized 1α(OH)D 3 to the active metabolite(s), possibly 1α,24‐ and/or 1α, 25‐dihydroxyvitamin D 3 , and these cells were efficiently induced to differentiate by treatment with 1α(OH)D 3 . However, the other types of leukemia cells did not efficiently metabolize it and were not induced to differentiate by 1α(OH)D 3 . The possible therapeutic advantage of 1α(OH)D 3 in the treatment of monocytic leukemia is discussed.