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Parental imprinting of the human H19 gene
Author(s) -
Rachmilewitz Jacob,
Goshen Ran,
Ariel Ilana,
Schneider Tamar,
de Groot Nathan,
Hochberg Abraham
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80731-u
Subject(s) - imprinting (psychology) , genomic imprinting , gene , genetics , biology , gene expression , dna methylation
It has only recently become clear that genetic imprinting plays an important role in human embryogenesis and in processes leading to the development of pediatric cancers and other human diseases. Using a unique human tissue, the androgenetic complete hydatidiform mole, we established that the maternally inherited allele of the imprinted H19 gene is expressed. Our results also show that the paternal allele of the human IGF‐II gene, a gene suspected to be parentally imprinted in humans, is expressed.