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How is rat liver S ‐adenosylmethionine synthetase regulated?
Author(s) -
Pajares Maria A.,
Corrales Fernando,
Durán Cristina,
Mato José M.,
Alvarez Luis
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80726-w
Subject(s) - phosphorylation , glutathione , enzyme , biochemistry , methionine , in vivo , chemistry , metabolism , biology , amino acid , genetics
The in vivo regulation of S ‐adenosylmethionine synthetase, a key enzyme in methionine metabolism, is so far unknown. The enzyme activity has been shown to be modulated by glutathione and the oxidation state of its sulfhydryl groups. Analysis of the protein sequence has revealed the presence of putative phosphorylation sites. A mixed regulatory mechanism combining phosphorylation and the oxido/reduction of sulfhydryl groups is proposed. The role of glutathione in this mechanism is also discussed.