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Insulin‐like growth factor II stimulates glucose transport in human skeletal muscle
Author(s) -
Zierath Juleen R.,
Bang Peter,
Galuska Dana,
Hall Kerstin,
Wallberg-Henriksson Harriet
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80717-u
Subject(s) - skeletal muscle , glucose transporter , endocrinology , medicine , chemistry , insulin , growth factor , glucose uptake , insulin like growth factor , carbohydrate metabolism , biology , receptor
We investigated the effect of insulin‐like growth factor II (IGF‐II) and insulin‐like growth factor binding protein‐1 (IGFBP‐1) on 3‐ O ‐methylglucose transport in incubated human skeletal muscle strips. Increasing physiological concentrations of IGF‐II stimulated glucose transport in a dose‐dependent manner. Glucose transport was maximally stimulated in the presence of 100 ng/ml (13.4 nM) of IGF‐II, which corresponded to the effect obtained by 100μU/ml (0.6 nM) of insulin. Exposure of muscle strips to IGFBP‐1 (500 ng/ml) inhibited the maximal effect of IGF‐II on glucose transport by 40%. Thus, it is conceivable that IGF‐II and IGFBP‐I are physiological regulators of the glucose transport process in human skeletal muscle.