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Isolation of a new ligand‐carrying casein fragment from bovine mammary gland microsomes
Author(s) -
Neuteboom Ben,
Giuffrida Maria Gabriella,
Conti Amedeo
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80664-3
Subject(s) - mammary gland , biochemistry , ligand (biochemistry) , microsome , casein , retinol , chemistry , retinol binding protein , biology , microbiology and biotechnology , receptor , enzyme , vitamin , genetics , cancer , breast cancer
Whilst looking for components involved in retinol metabolism in secreting mammary gland cells, a 12 kDa Protein was isolated. This protein had bound a ligand with characteristics of retinol. N‐Terminal sequencing and amino acid analysis showed that this protein is highly homologous with an α‐sl‐casein fragment. No ligand was found for β‐lactoglobulin, previously thought to be involved in retinol metabolism.