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The envelope glycoprotein of Ebola virus contains an immunosuppressive‐like domain similar to oncogenic retroviruses
Author(s) -
Volchkov Viktor E.,
Blinov Vladimir M.,
Netesov Sergey V.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80662-z
Subject(s) - open reading frame , biology , ebola virus , homology (biology) , virology , gene , complementary dna , genetics , peptide sequence , rna , glycoprotein , virus , microbiology and biotechnology
Genomic RNA of a Zaire strain of Ebola virus was cloned, and cDNA inserts specific for the glycoprotein gene were isolated and sequenced. The determined sequence has only one open reading frame encoding 318 amino acids and is part of ORF‐4 on the plus RNA strand. The putative transcriptional stop site (3′ AAUUC 5′) and the transcriptional start site (3′ AACUACUUCUAAUU.. 5′) were identified. Computer‐assisted comparison of the amino acid sequence of the C‐terminal part of protein encoded by ORF‐4 of Ebola virus with sequence of the proteins present in the SWISSPROT and EMBL banks revealed significant homology with the immunosuppressive domain of the p15E envelope proteins of various oncogenic retroviruses. The possible role of such a homology is discussed.