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Heterogeneous expression of four MAP kinase isoforms in human tissues
Author(s) -
Gonzalez Fernando A.,
Raden David L.,
Rigby Mark R.,
Davis Roger J.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80612-k
Subject(s) - gene isoform , mitogen activated protein kinase , signal transduction , biology , kinase , mapk7 , map2k7 , gene , map kinase kinase kinase , mapk14 , microbiology and biotechnology , genetics , protein kinase a , computational biology , cyclin dependent kinase 2
Mitogen‐activated protein kinases (MAP kinases) are a group of closely related enzymes implicated in signal transduction pathways. We report the molecular cloning of four human proteins (p40 mapk , p41 mapk , p44 mapk and p63 mapk , with high homology to members of the MAP kinase family. Sequence analysis demonstrated that p44 mapk and p63 mapk were the products of distinct genes. However, the p40 mapk and p41 mapk were found to be related, and are likely to result from alternative processing of transcripts from a single gene. The heterogeneous expression of these human MAP kinase isoforms in different tissues may reflect the diversity of signal transduction pathways in differentiated cells.