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Polyamines enhance calcium mobilization in fMet‐Leu‐Phe‐stimulated phagocytes
Author(s) -
Walters John D.,
Sorboro David M.,
Chapman Kena J.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80584-4
Subject(s) - cytosol , putrescine , spermidine , microbiology and biotechnology , chemistry , biochemistry , kinase , calcium , biology , enzyme , organic chemistry
Spermidine and putrescine (50 μM‐1 mM), found in exudates from infection sites, significantly enhance fMet‐Leu‐Phe‐induced Ca 2+ mobilization in differentiated HL‐60 cells and polymorphonuclear leukocytes (PMNs) by delaying the return to basal cytosolic Ca 2+ levels. This enhancement by polyamines is associated with inhibition of Ca 2+ efflux across the plasma membrane. In parallel with their effects on Ca 2+ signaling, polyamines also significantly prolong the kinetics of fMet‐Leu‐Phe‐induced protein kinase C translocation. Thus, polyamines may play a novel role in modulating regulatory events in phagocytes.