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Relationship of neural cell adhesion molecules (N‐CAMs) with adenylate cyclase
Author(s) -
Lipkin V.M.,
Surina E.A.,
Petukhova G.V.,
Petrov V.M.,
Mirzoeva S.F.,
Rakitina T.V.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80577-4
Subject(s) - cyclase , adenylate kinase , polyclonal antibodies , calmodulin , xenopus , biochemistry , microbiology and biotechnology , complementary dna , biology , chemistry , antibody , gene , enzyme , genetics
Bovine brain cDNA cloned earlier and attributed to calmodulin‐independent adenylate cyclase encodes the neural cell adhesion molecule (N‐CAM). The expression of N‐CAM mRNA in Xenopus laevis oocytes increases their basal adenylate cyclase activity. Polyclonal antibodies against synthetic peptide A, VAENQQGKSKAAHFV (664–678 amino acid residues of bovine N‐CAM), containing sequence AXXXXGKS which is homologous to the nucleotide‐binding consensus sequence GXXXXGKS, inhibit the adenylate cyclase activity. A close relationship appears to exist between adenylate cyclase and N‐CAM.