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Inhibition of pigeon breast muscle α‐ketoglutarate dehydrogenase by phosphonate analogues of α‐ketoglutarate
Author(s) -
Victoria I. Bunik,
A.I. Biryukov,
Yu. N. Zhukov
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80518-l
Subject(s) - phosphonate , chemistry , alpha ketoglutarate , isomerization , enzyme , biochemistry , dehydrogenase , stereochemistry , catalysis
Succinylphosphonate (SP) is a powerful inhibitor or α‐ketoglutarate dehydrogenase (KGD). Methylation of the phosphonate reduces its inhibitory effect. The complex of KGD with SP undergoes a kinetically slow transition similar to the process observed during catalysis. α‐Ketoglutarate binds to the enzyme—inhibitor complex, preventing its isomerisation.