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Anion permeation limits the uncoupling activity of fatty acids in mitochondria
Author(s) -
Peter Schönfeld
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80516-j
Subject(s) - oligomycin , chemistry , permeation , fatty acid , respiration , mitochondrion , ammonium , membrane , biochemistry , inner mitochondrial membrane , biology , organic chemistry , enzyme , atpase , botany
The action of such membrane‐permeant cations as tetraphenyl phosphonium and dibenzyldimethyl ammonium upon fatty acid‐uncoupled respiration has been studied with oligomycin‐inhibited rat liver mitochondria. Both cations enhance fatty acid‐stimulated respiration. This synergistic effect is explained by a facilitated permeation of the fatty acid anion across the inner membrane due to an ion‐pair complex. It is concluded that fatty acid uncoupling in rat liver mitochondria is limited by fatty acid anion permeation.