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Expression pattern of the activin receptor type IIA gene during differentiation of chick neural tissues, muscle and skin
Author(s) -
Hideyo Ohuchi,
Simihare Noji,
Eiki Koyama,
Fumio Myokai,
Kiyoshi Nishikawa,
Tsutomu Nohno,
Kosuke Tashiro,
K. Shiokawa,
Nobuhiko Matsuo,
Shigehiko Taniguchi
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80515-i
Subject(s) - neuroectoderm , ectoderm , mesoderm , biology , activin receptor , epidermis (zoology) , in situ hybridization , microbiology and biotechnology , embryo , receptor , notochord , spinal cord , endocrinology , gene expression , gene , anatomy , embryogenesis , transforming growth factor , embryonic stem cell , genetics , neuroscience
To elucidate target cells of activins during embryogenesis we isolated cDNAs of chick activin receptor type II ( cActR‐II ) and studied expression patterns of the cActR‐II gene by in situ hybridization. Transcripts of cActR‐II were observed in neuroectoderm developing to spinal cord, brain and eyes, in surface ectoderm differentiating to epidermis, and in myotomes differentiating to muscles. The expression patterns of cActR‐II suggest that activin and its receptor are involved in differentiation of chick neural tissues, muscle and skin after inducing the dorsal mesoderm.