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Multiple genes for Xenopus activin receptor expressed during early embryogenesis
Author(s) -
Nishimatsu Shin-ichiro,
Oda Satoshi,
Murakami Kazuo,
Ueno Naoto
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80482-v
Subject(s) - xenopus , biology , complementary dna , microbiology and biotechnology , northern blot , acvr2b , transmembrane protein , transmembrane domain , gene , activin receptor , protein kinase domain , cdna library , receptor , genetics , mutant , superfamily
Four distinct cDNAs for activin receptor designated as XSTK2, 3, 8 and 9 have been cloned from a Xenopus laevis cDNA library. The protein structures deduced from the cDNAs have shown that they all have a putative extracellular ligand‐binding domain, a single transmembrane domain and cytoplasmic Ser/Thr kinase domain, except that XSTK2 is extremely similar to the XSTK3 gene but lacks a carboxyl‐terminal part of the kinase motif. Northern blot analysis showed that all transcripts are maternally inherited. The levels or transcript for XSTK2, 3 and 8 appeared to fluctuate during early development while those for XSTK9 maintain constant.