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Differential expression of two sodium channel subtypes in human brain
Author(s) -
Lu Chiung-Mei,
Han Jian,
Rado Thomas A.,
Brown George B.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80476-w
Subject(s) - human brain , complementary dna , microbiology and biotechnology , biology , genetics , gene , neuroscience
Two partial human brain sodium channel cDNA sequences (designated HBSC I and II) have been cloned and mapped to chromosome 2q23–2q24 by chromosome microdissection‐PCR (CMPCR). The distribution of HBSC I and II mRNA in human brain was studied by means of a novel approach based on the ligase detection reaction. These studies demonstrate that HBSC I and II mRNA is heterogeneously distributed in brain. and that the relative ratio or the two forms can vary as much as 7‐fold between different regions.