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Three‐dimensional structural resemblance between leucine aminopeptidase and carboxypeptidase A revealed by graph‐theoretical techniques
Author(s) -
Artymiuk Peter J.,
Grindley Helen M.,
Park Julie E.,
Rice David W.,
Willett Peter
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80475-v
Subject(s) - carboxypeptidase , aminopeptidase , structural similarity , leucyl aminopeptidase , carboxypeptidase a , leucine , biochemistry , graph , similarity (geometry) , chemistry , biology , computational biology , enzyme , amino acid , computer science , mathematics , artificial intelligence , combinatorics , image (mathematics)
Using 3‐D searching techniques based on algorithms derived from graph theory we have established a striking structural similarity between the structure or bovine carboxypeptidase A and that of the C‐terminal domain of bovine leucine aminopeptidase. There is no significant sequence homology between the aminopeptidases and the carboxypeptidases but the strong structural relationship detected in this complex fold suggests that there may be a very remote divergent evolutionary relationship between these two enzyme classes.