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Interleukin‐4 stimulates collagen gene expression in human fibroblast monolayer cultures Potential role in fibrosis
Author(s) -
Gillery P.,
Fertin C.,
Nicolas J.F.,
Chastang F.,
Kalis B.,
Banchereau J.,
Maquart F.X.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80448-p
Subject(s) - fibroblast , fibrosis , chemistry , interleukin , gene expression , pathophysiology , microbiology and biotechnology , in vitro , immunology , biology , cytokine , gene , endocrinology , medicine , biochemistry
A role for the cytokines produced by tissue‐infiltrated inflammatory cells (mainly T‐lymphocytes and must cells) in the pathophysiology of fibrosis has been suggested by several groups. Among the products of these cells, interleukin‐4 (IL‐4) might be one of the factors involved in the initiation of the fibrotic process. We studied the effects of recombinant human IL‐4 on human fibroblast monolayer cultures. IL‐4 (10 and 100 U/ml) induced a dose‐dependent increase of collagen production. Non‐collagen protein synthesis was not significantly altered. A concomitant increase of pro‐α1(I) collagen mRNAs was observed, showing that IL‐4 acts at a pre‐translational level.