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Nitrendipine is a potent inhibitor of the Ca 2+ ‐activated K + channel of human erythrocytes
Author(s) -
Ellory J.Clive,
Kirk Kiaran,
Culliford Steven J.,
Nash Gerard B.,
Stuart John
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80383-r
Subject(s) - nitrendipine , ionophore , ionomycin , chemistry , channel blocker , efflux , biophysics , membrane , calcium , biochemistry , intracellular , biology , organic chemistry
Nitrendipine, a classical blocker of L‐type Ca 2+ channels, is shown to be a potent inhibitor of the Ca 2+ ‐activated K + channel of human erythrocytes. In erythrocytes suspended in a solution with physiological Na + and K + concentrations and in which the channel was activated using the Ca 2+ ionophore ionomycin, nitrendipene inhibited K + ( 80 Rb + ) influx with an I 50 of around 130 nM. Similar results were obtained for K + ( 80 Rb + ) efflux, and for K + ( 80 Rb + ) influx into cells suspended in a high‐K + medium.