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The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptor
Author(s) -
Dini Luciana,
Autuori Francesco,
Lentini Alessandro,
Oliverio Serafina,
Piacentini Mauro
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80373-o
Subject(s) - asialoglycoprotein receptor , apoptosis , microbiology and biotechnology , receptor , cell , parenchyma , chemistry , biology , hepatocyte , biochemistry , in vitro , botany
Apoptosing cells are actively phagocytosed in parenchymal tissues, thus preventing the inflammatory reaction which could derive from their slow uncontrolled degradation. The molecular mechanisms by which an apoptotic cell is recognized and taken up are largely unknown. We propose that the recognition of apoptotic hepatocytes is mediated by the sugar recognition systems of the liver, particularly the asialoglycoprotein receptor (ASGP‐R). The results presented here demonstrate the participation of ASGP‐R in the removal of apoptotic parenchymal cells, and indicate a new perspective for the understanding of its physiological role.