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Rapid agonist‐induced beta‐adrenergic receptor kinase translocation in C6 glioma cells
Author(s) -
Garcia-Higuera Irene,
Mayor Federico
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80285-o
Subject(s) - homologous desensitization , adenylyl cyclase , agonist , beta adrenergic receptor kinase , receptor , adrenergic receptor , chemistry , beta 1 adrenergic receptor , protein kinase c , endocrinology , medicine , microbiology and biotechnology , biology , phosphorylation , g protein coupled receptor , biochemistry
Exposure of C6 glioma cells to 1 μM isoproterenol leads to fast desensitization of the β‐adrenergic receptor/adenylyl cyclase system and transient receptor sequestration. It also triggers a very rapid and transient translocation to the plasma membrane or β‐adrenergic receptor kinase (βARK), a specific cytoplasmic kinase that phosphorylates only the agonist‐occupied form of several G protein‐coupled receptors. βARK‐mediated receptor phosphorylation appears to be a suitable mechanism for the rapid regulation or adrenergic receptor function in the nervous tissue.